Summa of the Summas
Covid Inc has infected more people with Covid-19 genes more times in more tissues and organs in more serious ways and with much more serious consequences than the lowly Covid-19 virus ever could.
What I posted to some big substack guy:
The primary mechanism of action common to all viral mRNA products.
What follows is long, but at least it’s well-organized. I didn’t copy and paste any of it from anywhere. And I say that only because of certain folks, most often at Phys dot Org, the ones also most given to laughing emojis and fossilized AOL abbreviations, who have said (I imagine in the manner of Bill Murray’s Todd on SNL), “Nice job of copy and paste! ROTFLMAO 🤣”
I have long been able, from a very early age, to assimilate large amounts of information, recall it, and draw reliable conclusions from it. And, from a very early age, it’s also gotten me in trouble with teachers; a mostly worthwhile side effect.
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Since Covid-19 entered the public awareness, whether in my understanding of the scientific or the social engineering side of things, I’ve been right far more often than I’ve been wrong. My method has always been to find the simplest mechanism that can explain the greatest number of outcomes.
Because of my PhD and postdoctoral fellowship in molecular neurobiology and my long familiarity with the primary mechanism of action of these products for years before they ever appeared as “vaccines,” I recognized the viral mRNA products for what they were as soon as I heard they would use a viral gene.
Over the years since then, I have been more than a little amazed to see both supporters and opponents of the products talking about almost everything BUT the primary mechanism of action common to them all.
Opponents come up with all sorts of outlandish ideas about 5G-activated self-assembling nano-particles, snake venom, aborted babies, etc.
What I refer to as Covid Inc talks in generalities about its products only “giving your body the information it needs to build immunity.”
The truth is absurdly simple.
These products consist basically of two things:
1. A cell transfection reagent or method that functions as a vehicle.
2. A viral RNA or mRNA gene that is its cargo.
The cell transfection reagents and methods have been the backbone of molecular biological research, some for over 40 years.
There are basically 7 of them:
1. Electroporation
2. A microscopic needle (to inject genes directly into a single cell)
3. Magnetic field
4. Ultrasound
5. Nanoparticles
6. Lipid particles of various types
7. Replication-disabled adenoviruses
In my work I frequently used 1, 5, and 6.
The function of each of them is to introduce exogenous genes into living cells without killing them.
One purpose of number 1 is to introduce plasmids containing the gene of interest into bacteria that will copy the plasmids and produce a much larger number of them to be used in the process of molecular cloning. It’s an absolutely trivial thing to do. When I’m creating a gene construct of any kind, various cycles of this are necessary.
After the transgene has been constructed, the purpose of introducing it into a cell using a transfection reagent or method is to hijack the ribosomal protein synthesis machinery to automatically translate the mRNA into the protein it codes for.
The reason this is done in cell culture is to study the behavior of the resulting protein inside a little living laboratory of the cell without the complications of immune systems getting in the way.
In the lab I used method number 5, a nanoparticle calcium precipitate, for my transient transfections. That’s a way of producing a lot of exogenous protein rapidly. The particles contain circular vectors with my gene inserted. The particles stick to the outside of the cell membrane and are endocytosed. Once inside, the cell’s own machinery runs copies of mRNA off the gene in the vector. The mRNA is automatically fed into the ribosomes that translate it into protein. This is the method Pfizer uses, except instead of the gene contained in a vector, they start with pre-fabbed mRNA.
I also used method number 6, a lipid vehicle, to make my stable transfections, cells that will permanently express the exogenous gene and protein. Moderna and Johnson&Johnson use lipid particles to introduce vectors containing the C19 spike protein gene. These particles stick to and merge with the cell membrane’s lipid bilayer and translocate the vector with its gene into the cell. Once there, the cellular machinery automatically runs off mRNA copies of the exogenous gene. The mRNA is automatically taken up by the ribosomes that translate it into the exogenous protein.
AstraZeneca used method number 7, a replication-disabled chimp adenovirus, as its means of getting the viral gene cargo into cells. But unlike 5 and 6 that are indiscriminate, number 7 will dock only with cells containing a particular membrane surface receptor and activate it. The receptor translocates the virus into the cell where what happens with 5 and 6 will happen.
All these methods antedated their use by Covid Inc by decades. They are nothing new. Nothing special. They’re just old products being used in a novel, and dangerous, off-label fashion. And you’ll see that the ones that the different companies of Covid Inc spontaneously chose to introduce exactly the same viral gene all happen to be the most easily exploited of the seven for commercial purposes.
You can see that 5 and 6 are the functional equivalent of 7. And what 7 does is what any virus does: it sneaks its genome into healthy cells to replicate the genome and to make mRNA of all the separate viral genes to run off big loads of all the viral proteins that will reassemble around their viral genomes to make new viruses to continue the infection and replication process.
Numbers 5 and 6, therefore, are the artificial, functional equivalents of indiscriminate, one-gene, Covid-19 viruses; sure, they’re unable to make more viruses, but they’ll still have at least the same immunological effect as an actual virus and who needs to be able to replicate when that part of viral existence has been offloaded onto Covid Inc, with well over 25 billion doses delivered in less than 3.5 years. Which natural virus can do that?
Remember that in a flask of immortal cells, both cell transfection of an exogenous gene or infection by viruses will do the same thing: produce viral mRNA and viral proteins. But they won’t provoke immune response because flasks of cells have no immune system.
However, both cell transfection of an exogenous viral gene and infection of cells by a virus in a living organism, say, a human being, in addition to producing viral mRNA and viral proteins, will both do something else.
Cells contain sensors that detect the presence of viral mRNA and viral protein. Once they detect them, they signal the innate immune system that they have been compromised by viruses and are in the most dangerous stage of that compromise, which is viral replication.
It makes NO difference that the viral mRNA products have only a single viral gene to be transcribed into viral mRNA and will have only a single viral protein translated from that viral mRNA. The basic minimum condition for alerting the innate immune system to viral invasion is just detecting the presence of viral mRNA and viral protein.
Once the innate immune system is notified, it launches innate immune inflammatory attacks on the tissues and organs containing the compromised cells, regardless of whether they have been compromised by viruses or by artificial, functional equivalents of one-gene viruses.
So you lose a few cells, what’s the big deal?
Here’s the big deal.
When you’re infected by an actual virus, your innate immune system is getting notified about it from the very beginning. The innate immune system function is defense in depth: it focus on the location of the first signal and the degree of the signal strength.
The effect is to sequester the virus and to knock it off before it can spread. But in addition to the innate immune system responding to signaling by compromised cells, it can also detect the viral proteins that viruses are made of in the extra cellular fluid compartment and in the blood and whack them there, too, to help prevent other cells from getting infected.
So, by knowing the behavior of the innate immune system and the nature of viral mRNA products as they differ from viruses, you can predict the outcome from the parts of the mRNA products that behave exactly like viruses and from the parts that do not.
mRNA products are designed to be invisible to the innate immune system. Even the AstraZeneca chimp adenovirus was chosen because of its ability to fly under the innate immune radar.
So unlike viruses that are detected from the moment they invade a cell and then while they’re on their way to invade others, the viral mRNA products are not detected until after they invade cells.
And unlike the C19 viruses that first invade only cells in the respiratory tract expressing ACE2 cell surface receptors, the viral mRNA products using the cell transfection reagent types of numbers 5 and 6 can invade any cell of any organ they stick to.
And unlike C19 viruses that have one port of entry in the respiratory system and are attacked there from their earliest moments of entry in levels of innate immune inflammatory attack appropriate for low level and restricted location, the viral mRNA products, by design, inevitably and unavoidably enter many cells in many different organ systems, after which all of them start sounding the highest levels of alarm to the innate immune system.
And since the level of innate immune response is based on an in-depth defense strategy, the sudden appearance of mRNA product-compromised cells in multiple organ systems is the equivalent of a sudden multi-system viral attack. The innate immune system cannot respond in any other way but a multi-front, all-out, innate immune inflammatory attack. And some people just cannot survive that.
So, the above is one half of the problem presented by the viral mRNA products that is unlike either actual viruses or traditional viral protein vaccines.
The other half of the problem is that, unlike viral protein vaccines that contain viral protein fragments, the viral mRNA products produce simultaneously in multiple organ systems very large quantities of a physiologically-useless but biologically-active full length viral spike protein.
And here are some of the consequences of that.
1. The viral spike protein can cause the formation of giant multinucleated cells, even from cells of diverse tissue types. This is a disease process with a variety of outcomes, none good.
2. The viral spike protein can embed itself in cell membranes of cells other than the cells in which it originated. The immunological significance of this is that any cell sporting those proteins will be identified first by the innate immune system and attacked as a virally-compromised cell and then, when antibodies and T cells against the spike protein are generated, the antibodies will tag them, indicating they need to be taken out and the T cells will attack them.
3. Any viral spike proteins encountered in the extracellular fluid compartment by members of the innate immune system are identified as viruses. The innate immune system does not recognize viruses, only viral protein. So having many, many instances of that single viral protein diffused throughout the extracellular fluid compartment is seen by the innate immune system as many, many viruses. The many members of the innate immune system will collectively start generating a huge signal calling for a huge immune response. And in many viral diseases, such as the Spanish flu and smallpox, it’s the extremely strong immune response, not the virus, that kills people.
4. Spike proteins are capable of spontaneous multimerization. They can accrete to form large rafts of protein limited in size only by available spike protein.
5. The extracellular fluid compartment is drained by the lymphatic system. That drainage is dumped into the bloodstream through a port near the heart. If viral proteins are detected in the circulatory system
by the innate immune system, the innate immune system will respond in exactly the same way it would if the circulatory system were being flooded with viruses. Viremia triggers a very high level immune response.
6. Any of those spike protein rafts getting into the bloodstream will travel until they reach vessels too small to let them pass. This triggers clot formation and ischemic damage of tissue and organs downstream of the blockage.
And if all of this weren’t bad enough, C19 viral mRNA can be transcribed by cellular reverse transcriptase into a DNA-encoded form and inserted into the nuclear genome, you know, in the same way that happens with herpes simplex and herpes zoster. You think it’s gone away and then some sort of trigger causes those DNA-encoded viral genomes to be transcribed into mRNA and a whole new batch of infectious viruses are being produced and shed from one or another part of your anatomy.
But in the case of a single viral gene?
If the viral mRNA is produced and viral protein is translated, then those cells will call in an innate immune inflammatory attack.
I predict that many so-called autoimmune diseases will be found to originate from a single viral gene in whichever tissue was attacked by a virus specific for that tissue. And as the population of daughter cells grows from the original few that had the DNA-encoded gene inserted in its nuclear or even mitochondrial genome, then the severity of the “autoimmune” attacks on those organs will grow with time.
But consider these effects as mediated by viral mRNA products that are indiscriminate in the tissues and organs they attack.
The expected outcome would be populations of cells in many different organ systems with the viral gene in its DNA-encoded form inserted either in their nuclear or mitochondrial genomes, sitting there like little recurring unexploded bombs, just awaiting their own who-knows-what trigger to cause their expression and the subsequent innate immune inflammatory attacks on those organs.
So watch for an increase of “autoimmune” and multiple “autoimmune” disorders among the vaccinated and probably in a dose-dependent fashion.
So, to sum up, the companies of Covid Inc are responsible for infecting more people more times in more tissues and organs in more serious ways and with much more serious consequences than the lowly Covid-19 virus ever could.
Just the mechanisms I’ve described above and the immunological and other physical consequences of them, when combined with preexisting comorbidities and developmental changes from pre-birth through adolescence, as well as stem cell expression, are sufficient to explain almost the entirety of adverse outcomes of these products, virtually none of which would happen with a traditional viral protein vaccine.
Sincerely,
Gregorio Enrique Sandoval
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Photo by me, somewhere in Mexico, possibly El Parque Chapultepec
Yes, this looks like it could get progressively worse if I understand the author!? I know some unwise people are still taking these jabs! God help us all! What have these evil, greedy, big pharma pyschos done the the human race?!?!
This is going to be terrible. Is there any way to reverse this? How then shall we proceed?