Walter M Chesnut did say last year that bromelain had potential to be used as an inhibitor against SARS-CoV-2, but that more in vitro and in vivo testing is needed before reaching any firm conclusions. I don't think he was necessarily saying that it would be of much use if just taken orally as a supplement. I wonder if perhaps the entrails of a goat combined with eyes of a frog collected at dawn while a cock is crowing and then soaked in wormwood after being blessed by a priest might be more effective.
Great. I now disagree with the 4 articles I have read from you. One on Russell Brand, one on Malone and now serrapeptase and bromelain. Yes, both of these are dissolved by stomach acid. But they are protected by an enteric coating, a polymer. Acid won’t dissolve this polymer but the alkaline environment of the intestines will.
No, proteins aren’t dissolved by stomach acid, they are denatured, two entirely different things. If an aspirin dissolves in the stomach, its contents of salicylic acid (aspirin) maintains its identity. If a protein is denatured in the stomach by hydrochloric acid, its identity as that protein, including any function that protein could have under physiological conditions inside the body, is lost. I used human insulin produced by recombinant means as an example. It will work as insulin inside the body if you can get it there.
You can do that by injecting it. You can’t do it orally.
The same thing applies to those supplements marketed for building cartilage: they are cartilage proteins. But the only way they can help you to synthesize new cartilage inside your body is to be broken down into the smallest molecular components that can be translocated across the membranes of the brush border cells of the small intestines and that’s as single and double amino acids.
And I did mention that even if a protein makes it unscathed through stomach acid, the problem still remains of translocation across the brush border membrane in the small intestine.
The reason for stomach acid and peptidases is that without them your body can’t get the amino acids (especially the essential amino acids) it needs for protein synthesis.
If a foreign protein can make it into your body through the gut, it does so through leaky tight junctions between the cells of the gut lining and that’s a pathological condition.
That’s also one of the reasons that young infants are not to be given solid foods at too early an age. They still have leaky cell junctions in the gut and foreign proteins getting through them can lead to development of allergies, also a pathological condition.
Somewhere I recently saw my lecture notes about dietary proteins for the undergrad nutrition course. I’ll see if I can find them again.
As far as Malone’s patents are concerned, he may have patents on certain techniques that employ cell transfection reagents, but he is not to cell transfection reagents what Kerry Mullis was to PCR.
And, as I also pointed out, it’s not the cell transfection reagent that is dangerous, it’s how, when, and under which conditions it’s used that determines that:
1. In cell culture for molecular biology research? No problem—no direct danger to people
2. Introduced by injection into the human body for the purpose of introducing viral genes into healthy human cells? BIG problem—inherent, unavoidable, and serious danger.
Well first and most important we are on the same side wrt the DEATHVAX. I had 65 million views on Quora until they kicked me off. I asked for a reason - racist, misinformation, etc, etc. All I got was ‘we’re fed up of you’.
You know far more than I do about biology.i have a Ph.D but it’s in physics. However I’ve picked up a lot on my 5 year journey with this Covid scam. And physicists are making their mark, it’s a great science to cut through the murk.Rancourt has a great paper on Covid deaths by vaccination ( NOT Covid ) in the Southern hemisphere. Similarly Clauser ( Nobel prize for Quantum Entanglement work ) thinks CO2 Climate Change isn’t happening. It’s cloud cover from cosmic rays.
OK back to Nattokinase. And Bromelain. I had 3 blood clots followed by undiagnosed pneumonia in a Kenyan hospital. I was prescribed Rivaroxaban ( Xarelto ). Terrible stuff. A US doctor weaned me off it with Nattokinase, serrapeptase and vitamins K2 and D3. I dropped the serrapeptase but use Bromelain daily.
With enteric coatings these are NOT dissolved in the stomach by acid but reach my intestines where they are dissolved by the alkaline environment. Serrapeptase is the most fragile. Before enteric coatings it was all destroyed in the stomach. Yes injection will always be more efficient but this works.
When I went back to school to get the math and science I needed to apply for grad school, they had the trig-based and the calc-based engineering physics. I took the latter one. I didn’t have to, but I wasn’t taking the course just to get required credits.
I never did that in college. I took whatever was required by the major and then whatever I wanted to just because it was interesting. So I nearly always had an 18-22 hour course load.
Those two semesters in engineering physics and the labs were THE most enjoyable of all those classes that basically amounted to a post-bach pre-med degree, all the way from Intro Chem through Calc and Analytical Geometry 3.
I remember hearing of students going to another of the campuses to avoid our Chinese physics teacher. One of my chemistry teachers told me her daughter took his classes before going to UW for her mechanical engineering degree and had told her that she was very well prepared for everything that followed.
Our teacher told the class, mostly youngsters (I was about 40 then so I already knew it), that physics is not plugging numbers into formulas in calculators or looking things up in books.
He said you have to think physics. He said the only way you could even begin to design a solution to some problem was to be able to understand the physics involved. The only way to do that was to put it into your brain and the only effective way to do that was to memorize it.
Then, he said, you had at your mental fingertips what you needed to analyze the problem, but without being able to do that, you’re going to miss something and then bridges collapse and planes go down.
Ha ha ha ha ha.
Those poor young dopes growing up in schools where they almost never had to commit anything but little bits and pieces to memory. I could commit very large amounts of text to memory even at a young age.
He gave us handouts every day that we had to memorize and then we had daily tests outside of class on what we had memorized. I still have a two inch thick folder of those handouts. They were that good. And I have another of all the papers I wrote for our labs.
He’d say, “Those of you who are going into mechanical engineering, you do realize that each chapter of our physics book represents at least an entire course in your mechanical engineering program.”
So I was very well prepared by the time I started my PhD program, first in human nutrition/nutritional biology, up to the point I had gotten IRB and CRC approval for my thesis project in human energy metabolism (lipid usage and replenishment of intramuscular lipid pools) when my thesis advisor decided to take an offer of tenure at UW Madison; so then I started over on a molecular neurobiology thesis project in a neurobio/pharm/phys lab.
So I ended up spending 6.5 years altogether. Big deal. I was having fun and I came out of it with a lot broader background than most do. After that, 4 year post-doc on a cardiovascular training grant, then almost 16 years doing DNA sequencing and genotyping.
I guess that now after my two year break from almost 24 years of working 60-70 hours a week in labs, I’ll probably get another lab job.
Walter M Chesnut did say last year that bromelain had potential to be used as an inhibitor against SARS-CoV-2, but that more in vitro and in vivo testing is needed before reaching any firm conclusions. I don't think he was necessarily saying that it would be of much use if just taken orally as a supplement. I wonder if perhaps the entrails of a goat combined with eyes of a frog collected at dawn while a cock is crowing and then soaked in wormwood after being blessed by a priest might be more effective.
Great. I now disagree with the 4 articles I have read from you. One on Russell Brand, one on Malone and now serrapeptase and bromelain. Yes, both of these are dissolved by stomach acid. But they are protected by an enteric coating, a polymer. Acid won’t dissolve this polymer but the alkaline environment of the intestines will.
https://en.wikipedia.org/wiki/Enteric_coating
No, proteins aren’t dissolved by stomach acid, they are denatured, two entirely different things. If an aspirin dissolves in the stomach, its contents of salicylic acid (aspirin) maintains its identity. If a protein is denatured in the stomach by hydrochloric acid, its identity as that protein, including any function that protein could have under physiological conditions inside the body, is lost. I used human insulin produced by recombinant means as an example. It will work as insulin inside the body if you can get it there.
You can do that by injecting it. You can’t do it orally.
The same thing applies to those supplements marketed for building cartilage: they are cartilage proteins. But the only way they can help you to synthesize new cartilage inside your body is to be broken down into the smallest molecular components that can be translocated across the membranes of the brush border cells of the small intestines and that’s as single and double amino acids.
And I did mention that even if a protein makes it unscathed through stomach acid, the problem still remains of translocation across the brush border membrane in the small intestine.
The reason for stomach acid and peptidases is that without them your body can’t get the amino acids (especially the essential amino acids) it needs for protein synthesis.
If a foreign protein can make it into your body through the gut, it does so through leaky tight junctions between the cells of the gut lining and that’s a pathological condition.
That’s also one of the reasons that young infants are not to be given solid foods at too early an age. They still have leaky cell junctions in the gut and foreign proteins getting through them can lead to development of allergies, also a pathological condition.
Somewhere I recently saw my lecture notes about dietary proteins for the undergrad nutrition course. I’ll see if I can find them again.
As far as Malone’s patents are concerned, he may have patents on certain techniques that employ cell transfection reagents, but he is not to cell transfection reagents what Kerry Mullis was to PCR.
And, as I also pointed out, it’s not the cell transfection reagent that is dangerous, it’s how, when, and under which conditions it’s used that determines that:
1. In cell culture for molecular biology research? No problem—no direct danger to people
2. Introduced by injection into the human body for the purpose of introducing viral genes into healthy human cells? BIG problem—inherent, unavoidable, and serious danger.
Well first and most important we are on the same side wrt the DEATHVAX. I had 65 million views on Quora until they kicked me off. I asked for a reason - racist, misinformation, etc, etc. All I got was ‘we’re fed up of you’.
You know far more than I do about biology.i have a Ph.D but it’s in physics. However I’ve picked up a lot on my 5 year journey with this Covid scam. And physicists are making their mark, it’s a great science to cut through the murk.Rancourt has a great paper on Covid deaths by vaccination ( NOT Covid ) in the Southern hemisphere. Similarly Clauser ( Nobel prize for Quantum Entanglement work ) thinks CO2 Climate Change isn’t happening. It’s cloud cover from cosmic rays.
OK back to Nattokinase. And Bromelain. I had 3 blood clots followed by undiagnosed pneumonia in a Kenyan hospital. I was prescribed Rivaroxaban ( Xarelto ). Terrible stuff. A US doctor weaned me off it with Nattokinase, serrapeptase and vitamins K2 and D3. I dropped the serrapeptase but use Bromelain daily.
With enteric coatings these are NOT dissolved in the stomach by acid but reach my intestines where they are dissolved by the alkaline environment. Serrapeptase is the most fragile. Before enteric coatings it was all destroyed in the stomach. Yes injection will always be more efficient but this works.
Physics, the queen of science.
When I went back to school to get the math and science I needed to apply for grad school, they had the trig-based and the calc-based engineering physics. I took the latter one. I didn’t have to, but I wasn’t taking the course just to get required credits.
I never did that in college. I took whatever was required by the major and then whatever I wanted to just because it was interesting. So I nearly always had an 18-22 hour course load.
Those two semesters in engineering physics and the labs were THE most enjoyable of all those classes that basically amounted to a post-bach pre-med degree, all the way from Intro Chem through Calc and Analytical Geometry 3.
I remember hearing of students going to another of the campuses to avoid our Chinese physics teacher. One of my chemistry teachers told me her daughter took his classes before going to UW for her mechanical engineering degree and had told her that she was very well prepared for everything that followed.
Our teacher told the class, mostly youngsters (I was about 40 then so I already knew it), that physics is not plugging numbers into formulas in calculators or looking things up in books.
He said you have to think physics. He said the only way you could even begin to design a solution to some problem was to be able to understand the physics involved. The only way to do that was to put it into your brain and the only effective way to do that was to memorize it.
Then, he said, you had at your mental fingertips what you needed to analyze the problem, but without being able to do that, you’re going to miss something and then bridges collapse and planes go down.
Ha ha ha ha ha.
Those poor young dopes growing up in schools where they almost never had to commit anything but little bits and pieces to memory. I could commit very large amounts of text to memory even at a young age.
He gave us handouts every day that we had to memorize and then we had daily tests outside of class on what we had memorized. I still have a two inch thick folder of those handouts. They were that good. And I have another of all the papers I wrote for our labs.
He’d say, “Those of you who are going into mechanical engineering, you do realize that each chapter of our physics book represents at least an entire course in your mechanical engineering program.”
So I was very well prepared by the time I started my PhD program, first in human nutrition/nutritional biology, up to the point I had gotten IRB and CRC approval for my thesis project in human energy metabolism (lipid usage and replenishment of intramuscular lipid pools) when my thesis advisor decided to take an offer of tenure at UW Madison; so then I started over on a molecular neurobiology thesis project in a neurobio/pharm/phys lab.
So I ended up spending 6.5 years altogether. Big deal. I was having fun and I came out of it with a lot broader background than most do. After that, 4 year post-doc on a cardiovascular training grant, then almost 16 years doing DNA sequencing and genotyping.
I guess that now after my two year break from almost 24 years of working 60-70 hours a week in labs, I’ll probably get another lab job.
Good for you Gregorio!